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KMID : 1149220000080010129
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Korean Journal of Oriental Medical Prescription
2000 Volume.8 No. 1 p.129 ~ p.146
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Effects of Solanum lyratum on The CCl₄-indused Liver Damage in mice
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Park Chul-Soo
Lee Won-Hoon
Kim Seon-Kang
Kim Jong-Dae
Park Sun-Dong
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Abstract
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This study was carried out to investigate the effects of Solanum lyratum Extract (SLE) on the recovery of liver in CCl₄-intoricated mice. In this study, ICR-Mice were divided into 3 experimental groups; Normal group was fed basal diet and was fed bassal diet for 2 Weeks, sample group was injected CCl₄ and was fed basal diet for 2 weeks, sample group was injected CCl₄ and was fed the SLE 500mg/kg fod 2 Weeks. In sample group, the level of serum AST, ALT, ALP activity decreased significantly compared with control group. This results suggest that SLE has appreciable therapeutic effect on CCl₄ induced hepatotoxicity. In sample group, the level of LPO in liver homogenates decreased significantly compared with control group. In sample group. the level of GSH, catalase in liver homogenates increased significantly compared with control group. This results suggest that SLE has appreciable antioxidant effect on CCl₄induced hepatotoxicity. In conclusion the results suggest that SLE has appreciable therapeutic effect and antioxidant effect on CCl₄ induced hepatotoxicity.
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KEYWORD
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Solanumlyratum, CCl₄, hepatotoxicity
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